Mentally Jacked

Tirzepatide Dosage Calculator

Calculate the reconstitution and exact units to draw for any tirzepatide dose. Tirzepatide follows a different titration ladder to semaglutide and reaches different maintenance doses, so the two are not interchangeable on a milligram basis.

Inputs
Draw to
25units
on your U-100, 1 ml syringe (100 u max)
Concentration10mg/ml
Volume to draw0.250ml
Doses per vial8shots
Instructions
  1. Reconstitute the 20 mg vial with 2 ml bacteriostatic water.
  2. Draw to 25 units on your U-100, 1 ml syringe (the red line).
  3. This delivers a dose of 2.5 mg (2500 mcg) per injection.
  4. Store the reconstituted vial refrigerated. Do not shake.

Educational tool only. Not medical advice. Always verify doses independently before use.

A dual agonist, not a stronger semaglutide

Tirzepatide activates both the GIP and GLP-1 receptors, whereas semaglutide acts on GLP-1 alone. That difference in mechanism produced greater average weight loss in head to head trials, and it also means milligram doses do not translate between the two medications. See the Semaglutide Dosage Calculator for a side-by-side comparison.

Titration and maintenance

Tirzepatide steps up in defined increments every four weeks as tolerated, with several recognised maintenance doses rather than a single target. Many people settle at a mid range dose that delivers the result they want without pushing to the maximum. Build the full dated schedule, including holds for side effects, in the GLP-1 Titration Calculator, or compare against the newer triple agonist in the Retatrutide Dosage Calculator.

FAQ

How do I reconstitute tirzepatide?

Add bacteriostatic water slowly down the side of the vial and swirl gently. The water volume determines your concentration and therefore the units per dose, so decide the mixing volume first and calculate from it.

Is tirzepatide stronger than semaglutide?

In head to head trials tirzepatide produced greater average weight loss. Milligram doses are not equivalent between the two, so switching requires recalculating rather than matching numbers.

How do I switch from semaglutide to tirzepatide?

Doses do not convert directly, and the usual approach is to start tirzepatide at a low step and titrate from there rather than attempting to match your previous dose. Discuss the transition with your prescriber.

What is the maximum tirzepatide dose?

The approved schedule tops out well above the starting dose, with recognised maintenance doses at several points along the way. Reaching the maximum is not a requirement or a goal in itself.

Does tirzepatide affect birth control?

It can reduce the effectiveness of oral contraceptives, particularly around dose escalation, because delayed gastric emptying affects absorption. Non-oral contraception is often recommended during that period.